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The RhoGAP Activity of Myosin IXB Is Critical for Osteoclast Podosome Patterning, Motility, and Resorptive Capacity

Osteoclasts are large, multinucleated cells of the monocyte-macrophage lineage that generate specialized substrate adhesion complexes to facilitate their function as bone-degrading cells. The patterning and function of these actin-based complexes, podosomes and sealing zones, are regulated by the sm...

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Bibliografiske detaljer
Main Authors: McMichael, Brooke K., Scherer, Katharine F., Franklin, Nicole C., Lee, Beth S.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3900720/
https://ncbi.nlm.nih.gov/pubmed/24466350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0087402
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