Chloroquine Is Grossly Under Dosed in Young Children with Malaria: Implications for Drug Resistance

BACKGROUND: Plasmodium falciparum malaria is treated with 25 mg/kg of chloroquine (CQ) irrespective of age. Theoretically, CQ should be dosed according to body surface area (BSA). The effect of dosing CQ according to BSA has not been determined but doubling the dose per kg doubled the efficacy of CQ...

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Main Authors: Ursing, Johan, Eksborg, Staffan, Rombo, Lars, Bergqvist, Yngve, Blessborn, Daniel, Rodrigues, Amabelia, Kofoed, Poul-Erik
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3900653/
https://ncbi.nlm.nih.gov/pubmed/24466245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0086801
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