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Chloroquine Is Grossly Under Dosed in Young Children with Malaria: Implications for Drug Resistance

BACKGROUND: Plasmodium falciparum malaria is treated with 25 mg/kg of chloroquine (CQ) irrespective of age. Theoretically, CQ should be dosed according to body surface area (BSA). The effect of dosing CQ according to BSA has not been determined but doubling the dose per kg doubled the efficacy of CQ...

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Autors principals: Ursing, Johan, Eksborg, Staffan, Rombo, Lars, Bergqvist, Yngve, Blessborn, Daniel, Rodrigues, Amabelia, Kofoed, Poul-Erik
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3900653/
https://ncbi.nlm.nih.gov/pubmed/24466245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0086801
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