‘JD’ iPS cell–derived hepatocytes faithfully recapitulate the pathophysiology of familial hypercholesterolemia

Elevated levels of low density lipoprotein cholesterol (LDL-C) in plasma are a major contributor to cardiovascular disease (CVD), which is the leading cause of death worldwide. Genome–wide association studies (GWAS) have identified 95 loci that associate with control of lipid/cholesterol metabolism....

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Bibliographische Detailangaben
Hauptverfasser: Cayo, Max A., Cai, Jun, DeLaForest, Ann, Noto, Fallon K., Nagaoka, Masato, Clark, Brian S., Collery, Ross F., Si-Tayeb, Karim, Duncan, Stephen A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3900031/
https://ncbi.nlm.nih.gov/pubmed/22653811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.25871
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