Loss of unstably amplified dihydrofolate reductase genes from mouse cells is greatly accelerated by hydroxyurea.

Previous work has shown that mammalian cells that carry unstably amplified genes for dihydrofolate reductase (DHFR) gradually lose the amplified DHFR genes when grown in the absence of the DHFR inhibitor methotrexate (MTX). Unstably amplified genes occur on small acentric chromosomes called double m...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Snapka, R M, Varshavsky, A
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1983
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC389986/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6584871/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.80.24.7533
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