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Characterization of cleavage intermediate and star sites of RM.Tth111II

Tth111II is a thermostable Type IIGS restriction enzyme that recognizes DNA sites CAARCA (R = A or G) and cleaves downstream at N11/N9. Here, the tth111IIRM gene was cloned and expressed in E. coli, and Tth111II was purified. The purified enzyme contains internally-bound S-adenosylmethionine (SAM)....

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Autors principals: Zhu, Zhenyu, Guan, Shengxi, Robinson, Derek, Fezzazi, Hanna El, Quimby, Aine, Xu, Shuang-yong
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3899748/
https://ncbi.nlm.nih.gov/pubmed/24452415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep03838
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