Subunit Positioning and Stator Filament Stiffness in Regulation and Power Transmission in the V(1) Motor of the Manduca sexta V-ATPase()

The vacuolar H(+)-ATPase (V-ATPase) is an ATP-driven proton pump essential to the function of eukaryotic cells. Its cytoplasmic V(1) domain is an ATPase, normally coupled to membrane-bound proton pump V(o) via a rotary mechanism. How these asymmetric motors are coupled remains poorly understood. Low...

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Bibliographic Details
Main Authors: Muench, Stephen P., Scheres, Sjors H.W., Huss, Markus, Phillips, Clair, Vitavska, Olga, Wieczorek, Helmut, Trinick, John, Harrison, Michael A.
Format: Artigo
Language:Inglês
Published: Elsevier 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3899036/
https://ncbi.nlm.nih.gov/pubmed/24075871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2013.09.018
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