A Conserved Non-Canonical Docking Mechanism Regulates the Binding of Dual Specificity Phosphatases to Cell Integrity Mitogen-Activated Protein Kinases (MAPKs) in Budding and Fission Yeasts

Dual-specificity MAPK phosphatases (MKPs) are essential for the negative regulation of MAPK pathways. Similar to other MAPK-interacting proteins, most MKPs bind MAPKs through specific docking domains known as D-motifs. However, we found that the Saccharomyces cerevisiae MKP Msg5 binds the MAPK Slt2...

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Main Authors: Sacristán-Reviriego, Almudena, Madrid, Marisa, Cansado, José, Martín, Humberto, Molina, María
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2014
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3898958/
https://ncbi.nlm.nih.gov/pubmed/24465549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0085390
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