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Autoregulation of connexin43 gap junction formation by internally translated isoforms
During each heartbeat, intercellular electrical coupling via connexin43 (C×43) gap junctions enables synchronous cardiac contraction. In failing hearts, impaired C×43 trafficking reduces gap junction coupling, resulting in arrhythmias. Here we report that internal translation within C×43 (GJA1) mRNA...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3898934/ https://ncbi.nlm.nih.gov/pubmed/24210816 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2013.10.009 |
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