Dual targeting of glioblastoma multiforme with a proteasome inhibitor (Velcade) and a phosphatidylinositol 3-kinase inhibitor (ZSTK474)

Proteasome inhibitors have been proven to be effective anticancer compounds in many tumor models, including glioblastoma multiforme (GBM). In this study, we found that the proteasome inhibitor Velcade (PS-341/bortezomib) caused GBM cell death while simultaneously activating the PI3K/Akt pathway. The...

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Main Authors: LIN, LEHANG, GAUT, DARIA, HU, KAISHUN, YAN, HAIYAN, YIN, DONG, KOEFFLER, H. PHILLIP
Formato: Artigo
Idioma:Inglês
Publicado: D.A. Spandidos 2013
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3898871/
https://ncbi.nlm.nih.gov/pubmed/24297065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ijo.2013.2205
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