STAT3 activation in HER2-overexpressing breast cancer promotes epithelial-mesenchymal transition and cancer stem cell traits

Clinically, HER2 proto-oncogene amplification is found in about 25–30% of human breast cancers, where it is correlated to a poor prognosis. Constitutive STAT3 activation is found in about 50–60% of the breast tumors and associated with tumorigenesis and drug resistance. In this study, we showed that...

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Bibliographic Details
Main Authors: CHUNG, SEYUNG S., GIEHL, NOLAN, WU, YANYUAN, VADGAMA, JAYDUTT V.
Format: Artigo
Language:Inglês
Published: D.A. Spandidos 2013
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3898805/
https://ncbi.nlm.nih.gov/pubmed/24297508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ijo.2013.2195
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