An NT4/TrkB-dependent increase in innervation links early-life allergen exposure to persistent airway hyperreactivity

Children who are exposed to environmental respiratory insults often develop asthma that persists into adulthood. In this study, we used a neonatal mouse model of ovalbumin (OVA)-induced allergic airway inflammation to understand the long-term effects of early childhood insults on airway structure an...

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Autori principali: Aven, Linh, Paez-Cortez, Jesus, Achey, Rebecca, Krishnan, Ramaswamy, Ram-Mohan, Sumati, Cruikshank, William W., Fine, Alan, Ai, Xingbin
Natura: Artigo
Lingua:Inglês
Pubblicazione: Federation of American Societies for Experimental Biology 2014
Soggetti:
Research Communications
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3898648/
https://ncbi.nlm.nih.gov/pubmed/24221086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.13-238212
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