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Induction of a type I interferon signature in normal human monocytes by gadolinium-based contrast agents: comparison of linear and macrocyclic agents

The gadolinium-based contrast agent (GdBCA) Omniscan activates human macrophages through Toll-like receptor (TLR)-4 and TLR-7 signalling. To explore the mechanisms responsible we compared the ability of linear and macrocyclic GdBCA to induce a type I interferon signature and a proinflammatory/profib...

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Detalhes bibliográficos
Main Authors: Wermuth, P J, Jimenez, S A
Formato: Artigo
Idioma:Inglês
Publicado em: British Society for Immunology 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3898560/
https://ncbi.nlm.nih.gov/pubmed/24111526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cei.12211
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