Metformin Retards Aging in C. elegans by Altering Microbial Folate and Methionine Metabolism

The biguanide drug metformin is widely prescribed to treat type 2 diabetes and metabolic syndrome, but its mode of action remains uncertain. Metformin also increases lifespan in Caenorhabditis elegans cocultured with Escherichia coli. This bacterium exerts complex nutritional and pathogenic effects...

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Main Authors: Cabreiro, Filipe, Au, Catherine, Leung, Kit-Yi, Vergara-Irigaray, Nuria, Cochemé, Helena M., Noori, Tahereh, Weinkove, David, Schuster, Eugene, Greene, Nicholas D.E., Gems, David
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3898468/
https://ncbi.nlm.nih.gov/pubmed/23540700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2013.02.035
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