Elevated Levels of Plasma Phenylalanine in Schizophrenia: A Guanosine Triphosphate Cyclohydrolase-1 Metabolic Pathway Abnormality?

BACKGROUND: Phenylalanine and tyrosine are precursor amino acids required for the synthesis of dopamine, the main neurotransmitter implicated in the neurobiology of schizophrenia. Inflammation, increasingly implicated in schizophrenia, can impair the function of the enzyme Phenylalanine hydroxylase...

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Detalhes bibliográficos
Main Authors: Okusaga, Olaoluwa, Muravitskaja, Olesja, Fuchs, Dietmar, Ashraf, Ayesha, Hinman, Sarah, Giegling, Ina, Hartmann, Annette M., Konte, Bettina, Friedl, Marion, Schiffman, Jason, Hong, Elliot, Reeves, Gloria, Groer, Maureen, Dantzer, Robert, Rujescu, Dan, Postolache, Teodor T.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3897774/
https://ncbi.nlm.nih.gov/pubmed/24465804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0085945
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