In Vivo Measurement of Hippocampal GABA(A)/cBZR Density with [(18)F]-Flumazenil PET for the Study of Disease Progression in an Animal Model of Temporal Lobe Epilepsy

PURPOSE: Imbalance of inhibitory GABAergic neurotransmission has been proposed to play a role in the pathogenesis of temporal lobe epilepsy (TLE). This study aimed to investigate whether [(18)F]-flumazenil ([(18)F]-FMZ) PET could be used to non-invasively characterise GABA(A)/central benzodiazepine...

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Detalhes bibliográficos
Main Authors: Vivash, Lucy, Gregoire, Marie-Claude, Bouilleret, Viviane, Berard, Alexis, Wimberley, Catriona, Binns, David, Roselt, Peter, Katsifis, Andrew, Myers, Damian E., Hicks, Rodney J., O'Brien, Terence J., Dedeurwaerdere, Stefanie
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3897736/
https://ncbi.nlm.nih.gov/pubmed/24466212
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0086722
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