Release of Tensile Strain on Engineered Human Tendon Tissue Disturbs Cell Adhesions, Changes Matrix Architecture, and Induces an Inflammatory Phenotype

Mechanical loading of tendon cells results in an upregulation of mechanotransduction signaling pathways, cell-matrix adhesion and collagen synthesis, but whether unloading removes these responses is unclear. We investigated the response to tension release, with regard to matrix proteins, pro-inflamm...

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Detalhes bibliográficos
Main Authors: Bayer, Monika L., Schjerling, Peter, Herchenhan, Andreas, Zeltz, Cedric, Heinemeier, Katja M., Christensen, Lise, Krogsgaard, Michael, Gullberg, Donald, Kjaer, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3897642/
https://ncbi.nlm.nih.gov/pubmed/24465881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0086078
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