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Crystallographic and Biochemical Analysis of the Mouse Poly(ADP-Ribose) Glycohydrolase

Protein poly(ADP-ribosyl)ation (PARylation) regulates a number of important cellular processes. Poly(ADP-ribose) glycohydrolase (PARG) is the primary enzyme responsible for hydrolyzing the poly(ADP-ribose) (PAR) polymer in vivo. Here we report crystal structures of the mouse PARG (mPARG) catalytic d...

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Bibliografiske detaljer
Main Authors: Wang, Zhizhi, Gagné, Jean-Philippe, Poirier, Guy G., Xu, Wenqing
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3897571/
https://ncbi.nlm.nih.gov/pubmed/24465839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0086010
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