NOS2 Is Critical to the Development of Emphysema in Sftpd Deficient Mice but Does Not Affect Surfactant Homeostasis

RATIONALE: Surfactant protein D (SP-D) has important immuno-modulatory properties. The absence of SP-D results in an inducible NO synthase (iNOS, coded by NOS2 gene) related chronic inflammation, development of emphysema-like pathophysiology and alterations of surfactant homeostasis. OBJECTIVE: In o...

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Hoofdauteurs: Knudsen, Lars, Atochina-Vasserman, Elena N., Guo, Chang-Jiang, Scott, Pamela A., Haenni, Beat, Beers, Michael F., Ochs, Matthias, Gow, Andrew J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2014
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3897517/
https://ncbi.nlm.nih.gov/pubmed/24465666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0085722
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