Spontaneous diabetes mellitus in transgenic mice expressing human islet amyloid polypeptide.

The islet in non-insulin-dependent diabetes mellitus (NIDDM) is characterized by loss of beta cells and large local deposits of amyloid derived from the 37-amino acid protein, islet amyloid polypeptide (IAPP). We have hypothesized that IAPP amyloid forms intracellularly causing beta-cell destruction...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Janson, J, Soeller, W C, Roche, P C, Nelson, R T, Torchia, A J, Kreutter, D K, Butler, P C
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1996
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC38975/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8692984/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.14.7283
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