Butyrate-induced colonic hypersensitivity is mediated by mitogen-activated protein kinase activation in rat dorsal root ganglia

OBJECTIVE: Increased faecal butyrate levels have been reported in irritable bowel syndrome. Rectal instillation of sodium butyrate (NaB) increases visceral sensitivity in rats by an unknown mechanism. We seek to examine the signal transduction pathways responsible for the enhanced neuronal excitabil...

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Main Authors: Xu, Dabo, Wu, Xiaoyin, Grabauskas, Gintautas, Owyang, Chung
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3897301/
https://ncbi.nlm.nih.gov/pubmed/22833396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gutjnl-2012-302260
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