Effects of a novel curcumin derivative on insulin synthesis and secretion in streptozotocin-treated rat pancreatic islets in vitro

BACKGROUND: Hyperglycemia induces activation of the c-Jun N-terminal kinase (JNK) pathway, which suppresses insulin gene expression and reduces DNA binding of pancreatic and duodenal homeobox factor (PDX)-1. This study aims to investigate the effects of a novel curcumin derivative (NCD) on JNK signa...

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Détails bibliographiques
Auteurs principaux: Aziz, Mohammed Talaat Abdel, El-Asmar, Mohammed Farid, Rezq, Ameen Mahmoud, Wassef, Mohammed Abdel Aziz, Fouad, Hanan, Roshdy, Nagwa Kamal, Ahmed, Hanan Hosni, Rashed, Laila Ahmed, Sabry, Dina, Taha, Fatma Mohammed, Hassouna, Amira
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2014
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3896850/
https://ncbi.nlm.nih.gov/pubmed/24422903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1749-8546-9-3
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