Downregulation of inhibitory SRC Homology 2 Domain-containing Phosphatase-1 (SHP-1) leads to recovery of T cell responses in elderly

BACKGROUND: Immune responses are generally impaired in aged mammals. T cells have been extensively studied in this context due to the initial discovery of their reduced proliferative capacity with aging. The decreased responses involve altered signaling events associated with the early steps of T ce...

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Main Authors: Le Page, Aurélie, Fortin, Carl, Garneau, Hugo, Allard, Nancy, Tsvetkova, Krassimira, Tan, Crystal Tze Ying, Larbi, Anis, Dupuis, Gilles, Fülöp, Tamas
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3896791/
https://ncbi.nlm.nih.gov/pubmed/24405902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1478-811X-12-2
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