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In vitro assessment of the effects of vedolizumab binding on peripheral blood lymphocytes
Vedolizumab (VDZ) is a humanized monoclonal antibody in development for the treatment of inflammatory bowel disease. VDZ binds to the α(4)β(7) integrin complex and inhibits its binding to mucosal addressin cell adhesion molecule-1 (MAdCAM-1), thus preventing lymphocyte extravasation to gut mucosal t...
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| Autori principali: | , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Landes Bioscience
2013
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3896598/ https://ncbi.nlm.nih.gov/pubmed/24492340 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.26392 |
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