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The WD40-repeat protein-containing deubiquitinase complex: catalysis, regulation, and potential for therapeutic intervention

Ubiquitination has emerged as an essential signaling mechanism in eukaryotes. Deubiquitinases (DUBs) counteract the activities of the ubiquitination machinery and provide another level of control in cellular ubiquitination. Not surprisingly, DUBs are subjected to stringent regulations. Besides regul...

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Bibliografiske detaljer
Main Authors: Villamil, Mark A., Liang, Qin, Zhuang, Zhihao
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3896570/
https://ncbi.nlm.nih.gov/pubmed/23797609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12013-013-9637-1
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