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Physalin H from Solanum nigrum as an Hh signaling inhibitor blocks GLI1–DNA-complex formation

Hedgehog (Hh) signaling plays an important role in embryonic development, cell maintenance and cell proliferation. Moreover, Hh signaling contributes to the growth of cancer cells. Physalins are highly oxidized natural products with a complex structure. Physalins (1–7) were isolated from Solanum nig...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
Main Authors: Arai, Midori A, Uchida, Kyoko, Sadhu, Samir K, Ahmed, Firoj, Ishibashi, Masami
פורמט: Artigo
שפה:Inglês
יצא לאור: Beilstein-Institut 2014
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3896228/
https://ncbi.nlm.nih.gov/pubmed/24454566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3762/bjoc.10.10
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