Physalin H from Solanum nigrum as an Hh signaling inhibitor blocks GLI1–DNA-complex formation

Hedgehog (Hh) signaling plays an important role in embryonic development, cell maintenance and cell proliferation. Moreover, Hh signaling contributes to the growth of cancer cells. Physalins are highly oxidized natural products with a complex structure. Physalins (1–7) were isolated from Solanum nig...

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Bibliographic Details
Main Authors: Arai, Midori A, Uchida, Kyoko, Sadhu, Samir K, Ahmed, Firoj, Ishibashi, Masami
Format: Artigo
Language:Inglês
Published: Beilstein-Institut 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3896228/
https://ncbi.nlm.nih.gov/pubmed/24454566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3762/bjoc.10.10
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