Oncogenic KIT-containing exosomes increase gastrointestinal stromal tumor cell invasion

During tumor development, constant interplay occurs between tumor cells and surrounding stromal cells. We report evidence that gastrointestinal stromal tumor (GIST) cells invade the interstitial stroma through the release of the oncogenic protein tyrosine kinase (KIT)-containing exosomes, which trig...

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Bibliographic Details
Main Authors: Atay, Safinur, Banskota, Samagya, Crow, Jennifer, Sethi, Geetika, Rink, Lori, Godwin, Andrew K.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2014
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3896203/
https://ncbi.nlm.nih.gov/pubmed/24379393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1310501111
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