A unique squalenoylated and nonpegylated doxorubicin nanomedicine with systemic long-circulating properties and anticancer activity

We identified that the chemical linkage of the anticancer drug doxorubicin onto squalene, a natural lipid precursor of the cholesterol’s biosynthesis, led to the formation of squalenoyl doxorubicin (SQ-Dox) nanoassemblies of 130-nm mean diameter, with an original “loop-train” structure. This unique...

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Bibliographische Detailangaben
Hauptverfasser: Maksimenko, Andrei, Dosio, Franco, Mougin, Julie, Ferrero, Annalisa, Wack, Severine, Reddy, L. Harivardhan, Weyn, Andrée-Anne, Lepeltier, Elise, Bourgaux, Claudie, Stella, Barbara, Cattel, Luigi, Couvreur, Patrick
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2014
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PNAS Plus
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3896189/
https://ncbi.nlm.nih.gov/pubmed/24385587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1313459110
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