Interactions of Allelic Variance of PNPLA3 with Nongenetic Factors in Predicting Nonalcoholic Steatohepatitis and Nonhepatic Complications of Severe Obesity

OBJECTIVE: Allelic variation (rs738409C→G) in adiponutrin (patatin-like phospholipase domain-containing protein 3, PNPLA3) has been associated with hepatic steatosis and liver fibrosis. The physiologic impact of the PNPLA3 G allele may be exacerbated in patients with severe obesity. In this study, w...

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Main Authors: Guichelaar, M.M.J., Gawrieh, S., Olivier, M., Viker, K., Krishnan, A., Sanderson, S., Malinchoc, M., Watt, K.D., Swain, J.M., Sarr, M., Charlton, M.R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3896123/
https://ncbi.nlm.nih.gov/pubmed/23418085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/oby.20327
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