Characterization of the biological activity of a potent small molecule Hec1 inhibitor TAI-1

BACKGROUND: Hec1 (NDC80) is an integral part of the kinetochore and is overexpressed in a variety of human cancers, making it an attractive molecular target for the design of novel anticancer therapeutics. A highly potent first-in-class compound targeting Hec1, TAI-1, was identified and is character...

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Bibliografiska uppgifter
Huvudupphovsmän: Huang, Lynn YL, Lee, Ying-Shuan, Huang, Jiann-Jyh, Chang, Chia-chi, Chang, Jia-Ming, Chuang, Shih-Hsien, Kao, Kuo-Jang, Tsai, Yung-Jen, Tsai, Pei-Yi, Liu, Chia-Wei, Lin, Her-Sheng, Lau, Johnson YN
Materialtyp: Artigo
Språk:Inglês
Publicerad: BioMed Central 2014
Ämnen:
Research
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3895848/
https://ncbi.nlm.nih.gov/pubmed/24401611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-9966-33-6
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