The effects of olanzapine on genome-wide DNA methylation in the hippocampus and cerebellum

BACKGROUND: The mechanism of action of olanzapine in treating schizophrenia is not clear. This research reports the effects of a therapeutic equivalent treatment of olanzapine on DNA methylation in a rat model in vivo. Genome-wide DNA methylation was assessed using a MeDIP-chip analysis. All methyla...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Melka, Melkaye G, Laufer, Benjamin I, McDonald, Patrick, Castellani, Christina A, Rajakumar, Nagalingam, O’Reilly, Richard, Singh, Shiva M
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2014
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3895844/
https://ncbi.nlm.nih.gov/pubmed/24382160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1868-7083-6-1
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