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Ribosome Formation is Blocked by Camptothecin, a Reversible Inhibitor of RNA Synthesis
A new drug, camptothecin, has been used to study the regulation of ribosome synthesis in HeLa cells. 5 μM camptothecin inhibits the synthesis of heterogeneously sedimenting nuclear RNA by about 70%. Camptothecin also blocks a specific step in the processing of ribosomal precursor RNA, allowing the c...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
1971
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC389580/ https://ncbi.nlm.nih.gov/pubmed/5289246 |
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