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Meclizine Enhancement of Sensorimotor Gating in Healthy Male Subjects with High Startle Responses and Low Prepulse Inhibition

Histamine H(1) receptor systems have been shown in animal studies to have important roles in the reversal of sensorimotor gating deficits, as measured by prepulse inhibition (PPI). H(1)-antagonist treatment attenuates the PPI impairments caused by either blockade of NMDA glutamate receptors or facil...

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Autori principali: Larrauri, José A, Kelley, Lisalynn D, Jenkins, Mason R, Westman, Eric C, Schmajuk, Nestor A, Rosenthal, M Zachary, Levin, Edward D
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3895242/
https://ncbi.nlm.nih.gov/pubmed/24045586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2013.248
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