Ex vivo induction of IFN-λ3 by a TLR7 agonist determines response to Peg-IFN/Ribavirin therapy in chronic hepatitis C patients

BACKGROUND: Genetic variation around interleukin-28B (IL28B), encoding IFN-λ3, predict non-responders to pegylated interferon-α/ribavirin (Peg-IFN/RBV) therapy in chronic hepatitis C (CHC). However, it remains unclear the expression and the role of IL28B itself. The aim of this study is to develop e...

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Detalhes bibliográficos
Main Authors: Murata, Kazumoto, Sugiyama, Masaya, Kimura, Tatsuji, Yoshio, Sachiyo, Kanto, Tatsuya, Kirikae, Ikue, Saito, Hiroaki, Aoki, Yoshihiko, Hiramine, Satoshi, Matsui, Teppei, Ito, Kiyoaki, Korenaga, Masaaki, Imamura, Masatoshi, Masaki, Naohiko, Mizokami, Masashi
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Japan 2013
Assuntos:
Original Article—Liver, Pancreas, and Biliary Tract
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3895210/
https://ncbi.nlm.nih.gov/pubmed/23591768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00535-013-0814-1
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