Surface-modified solid lipid nanoparticles for oral delivery of docetaxel: enhanced intestinal absorption and lymphatic uptake

Docetaxel is a potent anticancer drug, but development of an oral formulation has been hindered mainly due to its poor oral bioavailability. In this study, solid lipid nanoparticles (SLNs) surface-modified by Tween 80 or D-alpha-tocopheryl poly(ethylene glycol 1000) succinate (TPGS 1000) were prepar...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Cho, Hyun-Jong, Park, Jin Woo, Yoon, In-Soo, Kim, Dae-Duk
Format: Artigo
Langue:Inglês
Publié: Dove Medical Press 2014
Sujets:
Original Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3894956/
https://ncbi.nlm.nih.gov/pubmed/24531717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S56648
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