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A Glutathione-independent Glyoxalase of the DJ-1 Superfamily Plays an Important Role in Managing Metabolically Generated Methylglyoxal in Candida albicans

Methylglyoxal is a cytotoxic reactive carbonyl compound produced by central metabolism. Dedicated glyoxalases convert methylglyoxal to d-lactate using multiple catalytic strategies. In this study, the DJ-1 superfamily member ORF 19.251/GLX3 from Candida albicans is shown to possess glyoxalase activi...

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Detalhes bibliográficos
Main Authors: Hasim, Sahar, Hussin, Nur Ahmad, Alomar, Fadhel, Bidasee, Keshore R., Nickerson, Kenneth W., Wilson, Mark A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3894345/
https://ncbi.nlm.nih.gov/pubmed/24302734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.505784
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