TREM-1 Deficiency Can Attenuate Disease Severity without Affecting Pathogen Clearance

Triggering receptor expressed on myeloid cells-1 (TREM-1) is a potent amplifier of pro-inflammatory innate immune reactions. While TREM-1-amplified responses likely aid an improved detection and elimination of pathogens, excessive production of cytokines and oxygen radicals can also severely harm th...

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Hauptverfasser: Weber, Benjamin, Schuster, Steffen, Zysset, Daniel, Rihs, Silvia, Dickgreber, Nina, Schürch, Christian, Riether, Carsten, Siegrist, Mark, Schneider, Christoph, Pawelski, Helga, Gurzeler, Ursina, Ziltener, Pascal, Genitsch, Vera, Tacchini-Cottier, Fabienne, Ochsenbein, Adrian, Hofstetter, Willy, Kopf, Manfred, Kaufmann, Thomas, Oxenius, Annette, Reith, Walter, Saurer, Leslie, Mueller, Christoph
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2014
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3894224/
https://ncbi.nlm.nih.gov/pubmed/24453980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1003900
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