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Coarse-Grained Molecular Simulation of Epidermal Growth Factor Receptor Protein Tyrosine Kinase Multi-Site Self-Phosphorylation
Upon the ligand-dependent dimerization of the epidermal growth factor receptor (EGFR), the intrinsic protein tyrosine kinase (PTK) activity of one receptor monomer is activated, and the dimeric receptor undergoes self-phosphorylation at any of eight candidate phosphorylation sites (P-sites) in eithe...
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| Materialtyp: | Artigo |
| Språk: | Inglês |
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Public Library of Science
2014
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| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3894164/ https://ncbi.nlm.nih.gov/pubmed/24453959 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1003435 |
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