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Coarse-Grained Molecular Simulation of Epidermal Growth Factor Receptor Protein Tyrosine Kinase Multi-Site Self-Phosphorylation

Upon the ligand-dependent dimerization of the epidermal growth factor receptor (EGFR), the intrinsic protein tyrosine kinase (PTK) activity of one receptor monomer is activated, and the dimeric receptor undergoes self-phosphorylation at any of eight candidate phosphorylation sites (P-sites) in eithe...

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Bibliografiska uppgifter
Huvudupphovsman: Koland, John G.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2014
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3894164/
https://ncbi.nlm.nih.gov/pubmed/24453959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1003435
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