Neural Stem Cell Engraftment and Myelination in the Human Brain

Pelizaeus-Merzbacher disease (PMD) is a rare leukodystrophy caused by mutation of the proteolipid protein 1 gene. Defective oligodendrocytes in PMD fail to myelinate axons, causing global neurological dysfunction. Human central nervous system stem cells (HuCNS-SCs) can develop into oligodendrocytes...

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Hlavní autoři: Gupta, Nalin, Henry, Roland G., Strober, Jonathan, Kang, Sang-Mo, Lim, Daniel A., Bucci, Monica, Caverzasi, Eduardo, Gaetano, Laura, Mandelli, Maria Luisa, Ryan, Tamara, Perry, Rachel, Farrell, Jody, Jeremy, Rita J., Ulman, Mary, Huhn, Stephen L., Barkovich, A. James, Rowitch, David H.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3893824/
https://ncbi.nlm.nih.gov/pubmed/23052294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3004373
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