Promoter DNA methylation regulates progranulin expression and is altered in FTLD

BACKGROUND: Frontotemporal lobar degeneration (FTLD) is a heterogeneous group of neurodegenerative diseases associated with personality changes and progressive dementia. Loss-of-function mutations in the growth factor progranulin (GRN) cause autosomal dominant FTLD, but so far the pathomechanism of...

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Detalhes bibliográficos
Main Authors: Banzhaf-Strathmann, Julia, Claus, Rainer, Mücke, Oliver, Rentzsch, Kristin, van der Zee, Julie, Engelborghs, Sebastiaan, De Deyn, Peter P, Cruts, Marc, van Broeckhoven, Christine, Plass, Christoph, Edbauer, Dieter
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3893557/
https://ncbi.nlm.nih.gov/pubmed/24252647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2051-5960-1-16
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