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Excitotoxin-induced caspase-3 activation and microtubule disintegration in axons is inhibited by taxol

BACKGROUND: Axon degeneration, a key pathological event in many neurodegenerative diseases and injury, can be induced by somatodendritic excitotoxin exposure. It is currently unclear, however, whether excitotoxin-induced axon degeneration is mechanistically similar to Wallerian degeneration, which o...

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Detalhes bibliográficos
Main Authors: King, Anna Elizabeth, Southam, Katherine Adriana, Dittmann, Justin, Vickers, James Clement
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3893530/
https://ncbi.nlm.nih.gov/pubmed/24252213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2051-5960-1-59
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