Flagellin Treatment Prevents Increased Susceptibility to Systemic Bacterial Infection after Injury by Inhibiting Anti-Inflammatory IL-10+ IL-12- Neutrophil Polarization

Severe trauma renders patients susceptible to infection. In sepsis, defective bacterial clearance has been linked to specific deviations in the innate immune response. We hypothesized that innate immune modulations observed during sepsis also contribute to increased bacterial susceptibility after se...

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Detalhes bibliográficos
Main Authors: Neely, Crystal J., Kartchner, Laurel B., Mendoza, April E., Linz, Brandon M., Frelinger, Jeffrey A., Wolfgang, Matthew C., Maile, Robert, Cairns, Bruce A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3893295/
https://ncbi.nlm.nih.gov/pubmed/24454904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0085623
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