Monoclonal antibody therapeutics with up to five specificities: Functional enhancement through fusion of target-specific peptides

The recognition that few human diseases are thoroughly addressed by mono-specific, monoclonal antibodies (mAbs) continues to drive the development of antibody therapeutics with additional specificities and enhanced activity. Historically, efforts to engineer additional antigen recognition into molec...

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Detalhes bibliográficos
Main Authors: LaFleur, David W., Abramyan, Donara, Kanakaraj, Palanisamy, Smith, Rodger G., Shah, Rutul R., Wang, Geping, Yao, Xiao-Tao, Kankanala, Spandana, Boyd, Ernie, Zaritskaya, Liubov, Nam, Viktoriya, Puffer, Bridget A., Buasen, Pete, Kaithamana, Shashi, Burnette, Andrew F., Krishnamurthy, Rajesh, Patel, Dimki, Roschke, Viktor V., Kiener, Peter A., Hilbert, David M., Barbas III, Carlos F.
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2013
Assuntos:
Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3893231/
https://ncbi.nlm.nih.gov/pubmed/23575268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.23043
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