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A Simple Lattice Model That Captures Protein Folding, Aggregation and Amyloid Formation

The ability of many proteins to convert from their functional soluble state to amyloid fibrils can be attributed to inter-molecular beta strand formation. Such amyloid formation is associated with neurodegenerative disorders like Alzheimer's and Parkinson's. Molecular modelling can play a...

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Sonraí Bibleagrafaíochta
Main Authors: Abeln, Sanne, Vendruscolo, Michele, Dobson, Christopher M., Frenkel, Daan
Formáid: Artigo
Teanga:Inglês
Foilsithe: Public Library of Science 2014
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3893179/
https://ncbi.nlm.nih.gov/pubmed/24454816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0085185
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