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How Does Catalase Release Nitric Oxide? A Computational Structure Activity Relationship Study
Hydroxyurea (HU) is the only FDA approved medication for treating sickle cell disease in adults. The primary mechanism of action is pharmacological elevation of nitric oxide (NO) levels which induces propagation of fetal hemoglobin. HU is known to undergo redox reactions with heme based enzymes like...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3893047/ https://ncbi.nlm.nih.gov/pubmed/24087936 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ci400395c |
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