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Long-Lasting T Cell-Independent IgG Responses Require MyD88-Mediated Pathways and Are Maintained by High Levels of Virus Persistence

Many viruses induce acute T cell-independent (TI) B cell responses due to their repetitive epitopes and the induction of innate cytokines. Nevertheless, T cell help is thought necessary for the development of long-lasting antiviral antibody responses in the form of long-lived plasma cells and memory...

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Autors principals: Raval, Forum M., Mishra, Rabinarayan, Garcea, Robert L., Welsh, Raymond M., Szomolanyi-Tsuda, Eva
Format: Artigo
Idioma:Inglês
Publicat: American Society of Microbiology 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3892782/
https://ncbi.nlm.nih.gov/pubmed/24194540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.00812-13
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