Nitric Oxide Scavenging by Red Cell Microparticles and Cell Free Hemoglobin as a Mechanism for the Red Cell Storage Lesion

BACKGROUND: Intravascular red cell hemolysis impairs NO-redox homeostasis, producing endothelial dysfunction, platelet activation and vasculopathy. Red blood cell storage under standard conditions results in reduced integrity of the erythrocyte membrane, with formation of exocytic microvesicles or “...

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Detalhes bibliográficos
Main Authors: Donadee, Chenell, Raat, Nicolaas J.H., Kanias, Tamir, Tejero, Jesús, Lee, Janet S., Kelley, Eric E., Zhao, Xuejun, Liu, Chen, Reynolds, Hannah, Azarov, Ivan, Frizzell, Sheila, Meyer, E Michael, Donnenberg, Albert D., Qu, Lirong, Triulzi, Darrel, Kim-Shapiro, Daniel B., Gladwin, Mark T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3891836/
https://ncbi.nlm.nih.gov/pubmed/21747051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.110.008698
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