The study of novel DNA vaccines against tuberculosis: Induction of pathogen-specific CTL in the mouse and monkey models of tuberculosis

Results: HSP65 + IL-12 DNA vaccine showed higher protective efficacy compared with BCG in both mouse and monkey models of TB. It induced the TB-specific CTL in the mouse model of TB, while little level of activity was observed after the injection of BCG. It also showed strong therapeutic efficacy ag...

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Hlavní autoři: Okada, Masaji, Kita, Yoko, Nakajima, Toshihiro, Hashimoto, Satomi, Nakatani, Hitoshi, Nishimatsu, Shiho, Nishida, Yasuko, Kanamaru, Noriko, Kaneda, Yasuhumi, Takamori, Yasushi, McMurray, David, Tan, Esterlina V., Cang, Marjorie L., Saunderson, Paul, Dela Cruz, E.C.
Médium: Artigo
Jazyk:Inglês
Vydáno: Landes Bioscience 2013
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Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3891707/
https://ncbi.nlm.nih.gov/pubmed/23249543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/hv.23229
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