MLK3 promotes metabolic dysfunction induced by saturated fatty acid-enriched diet

Saturated fatty acids activate the c-Jun NH(2)-terminal kinase (JNK) pathway, resulting in chronic low-grade inflammation and the development of insulin resistance. Mixed-lineage kinase 3 (MLK3) is a mitogen-activated protein kinase kinase kinase (MAP3K) that mediates JNK activation in response to s...

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Autores principales: Gadang, Vidya, Kohli, Rohit, Myronovych, Andriy, Hui, David Y., Perez-Tilve, Diego, Jaeschke, Anja
Formato: Artigo
Lenguaje:Inglês
Publicado: American Physiological Society 2013
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3891220/
https://ncbi.nlm.nih.gov/pubmed/23860122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00197.2013
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